How to take AVONEX

One injection, once a week

AVONEX is a once-weekly treatment for relapsing multiple sclerosis (MS), offering you the flexibility to choose the day that works best for you. Talk to your healthcare provider to see if AVONEX may be right for you.

You have options for taking AVONEX

AVONEX is a 30 mcg intramuscular (into the muscle) self-injection, so you can take it in the comfort of your own home. AVONEX is available in one of 2 ways:


AVONEX PEN is a prefilled, single-dose autoinjector that lets you treat your relapsing MS in a single click. It includes a covered needle that's half the length of the standard needle for AVONEX prefilled syringe.

Download AVONEX PEN Instructions for Use

AVONEX prefilled syringe

AVONEX prefilled syringe lets you inject your weekly dose of AVONEX by following a step-by-step process.

Download AVONEX Prefilled Syringe Instruction for Use

How should I use AVONEX?

The injection process and recommended injection sites are different for each of these options.

See the Instructions for Use for detailed instructions for preparing and injecting your dose of AVONEX

A healthcare provider should show you how to prepare and measure your dose of AVONEX and how to inject your AVONEX before you use AVONEX for the first time

A healthcare provider or nurse should watch the first AVONEX injection you give yourself

AVONEX is given once a week by injection into the muscle (intramuscular injection)

Inject AVONEX exactly as your healthcare provider tells you

A healthcare provider will tell you how much AVONEX to inject and how often to inject AVONEX. Do not inject more than your healthcare provider tells you to

Do not change your dose unless your healthcare provider tells you to

Change (rotate) the injection site you choose with each injection. This will help decrease the chance that you will have an injection site reaction

Do not inject into an area of the body where the skin is irritated, reddened, bruised, infected or scarred in any way

AVONEX comes as a:

  • Prefilled syringe (can be used with the AVOSTARTGRIP® Titration Kit)
  • Single-dose prefilled autoinjector pen (AVONEX PEN®)
  • A healthcare provider will decide which one is best for you. See the Instructions for Use for detailed instructions for preparing and injecting your dose of AVONEX

After 2 hours, check your injection site for redness, swelling, or tenderness. If you have a skin reaction and it does not clear up in a few days, contact your healthcare provider

Always use a new, unopened AVONEX prefilled syringe or single-dose prefilled autoinjector pen for each intramuscular injection

More to check out

Biogen Support Services

If you’re living with relapsing MS, know that you’re not alone. Biogen Support Services is here to help

Get support today
Financial & Insurance Assistance

Get information on insurance coverage and financial assistance options, including the Biogen Copay Program if you are eligible*

Take a look
Questions for your
healthcare provider

Download a guide to help start a conversation with your healthcare provider about your relapsing MS treatment

Download guide

*Depending on your income or, in some cases, if your medication is obtained from an out-of-network provider, effective January 1, 2021 there is an annual cap that limits the amount of assistance that you can receive over one year. Federal and state laws and other factors may prevent or otherwise restrict eligibility. People covered by Medicare, Medicaid, the VA/DoD, or any other federal plans are not eligible to enroll. You may be eligible to enroll in the Biogen Copay Program for as long as it is offered and you are treated with a Biogen relapsing MS medication.

Watch the AVONEX
injection video

See how to prepare and give an injection with AVONEX PEN